Alzheimer's breakthrough as vaccine proves effective in study

Researchers at the University of Leicester and the University Medical Center Göttingen have just achieved a breakthrough that could lead to an effective treatment for Alzheimer’s disease.

If it proves successful in studies, it could revive millions of dementia misery.

It could also be given to patients as a simple vaccine.

Working with UK medical charity LifeArc, they found an antibody-based treatment and protein-based vaccine that will reduce Alzheimer’s symptoms in mouse models of the disease.

It was published in Molecular Psychiatry and outlines their transformative new approach to treating Alzheimer’s disease. Instead of targeting plaque build-up in the brain, they focused on a soluble form of the amyloid beta protein that could be more harmful to brain cells.

Professor Thomas Bayer: “We have chosen a different approach. We have identified an antibody in mice that neutralizes the shortened forms of the soluble beta-amyloid, but does not bind to normal forms of the protein or to the plaques.”

The antibody was then tested by Dr. Preeti Bakrania and LifeArc adapted so that the human body accepts it, not rejects it

The researchers saw the amyloid beta protein fold around itself, and Professor Mark Carr stated, “This structure has never been seen before in amyloid beta.”

The shape change gives scientists great hope to manipulate it and develop an effective vaccine against Alzheimer’s disease.

Is there a vaccine for Alzheimer’s disease?

When the results of the mouse models of the study are replicated in humans, an effective vaccine is an effective treatment Alzheimer’s could be open to the public within a decade.

Researchers found that their treatments helped restore neuron function, increase glucose metabolism in the brain and heal memory loss.

what is Alzheimer?

Dementia and Alzheimer’s disease are often confused. Put simply, Alzheimer’s is a form of dementia in which the brain atrophies (shrinks) and brain cells die.

Symptoms of Alzheimer’s can include memory loss, confused thinking, slow decision-making, and difficulty choosing the right word in conversations.

If you have any of these symptoms, you should contact your family doctor immediately.

The NHS offers a free health check-up to assess your general health for anyone between the ages of 40 and 74.

This can help doctors spot the early signs of Alzheimer’s and tell you if you’re at high risk. You can request your free check-up here.


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