The government will open a second headquarters for the housing division it announced in Wolverhampton.
There are currently no ministers in any department who regularly work outside of Whitehall.
The Department of Housing, Community and Local Government (MHCLG) will be the first to do this at the new Midlands base.
The move supports Boris Johnson’s promise to do more to create opportunities outside of London.
The Prime Minister’s so-called “leveling-up agenda” followed his landslide victory in 2019, in which parts of the north of England, the Midlands and North Wales voted for Tory after historically always voting for Labor.
Community secretary Robert Jenrick says there will be at least 500 roles in the West Midlands by 2025.
Officials will also work from the new headquarters in Wolverhampton.
Recruitment is ongoing, the department said, and the building for headquarters is expected to be announced in the spring.
Forty rolls were relocated to the region in the past year.
Mr Jenrick said, “With a dual headquarters in Wolverhampton, my department will change not only where we work but how we work, which signals that the end of Whitehall has the best approach.
“We are all looking forward to working there in the department.
“By choosing the city of Wolverhampton, we are also supporting our big smaller cities, some of which have been neglected for too long.
“We want to increase their stature, promote civic pride and economic success.”