Vaccination clinics have been instructed to start giving booster vaccinations “as soon as possible”.
The NHS bosses in England have sent a letter to all local health organizations with instructions for an imminent launch of the booster campaign.
The national booking system is expected to open to some people on Monday once they are eligible for the jab.
People will be asked to book six months after the second dose.
Most vaccination clinics will start the refresher program next week, but a small number of sites, including some hospitals, could start earlier.
And nursing home residents should expect to receive their booster vaccinations by the end of next month.
The letter states that in some hospitals, vaccination of health and social workers “can begin immediately”.
The Joint Vaccination and Immunization Committee (JCVI) on Tuesday unveiled its plan to booster vaccinations for more than 30 million British adults.
The JCVI expressed its preference for people to receive the Pfizer vaccine as a third dose, regardless of which vaccine they were originally given.
But it said half doses of the Moderna jab could be used as an alternative.
In the letter from Professor Sir Keith Willett and Dr. NHS England’s Nikita Kinnari says people will be offered the Pfizer / BioNTech vaccine and the Moderna vaccine will not be used in the program initially, but will be used at a later date.
Regarding co-administration of the flu shot, health leaders said that consideration should be given “wherever eligibility for both programs, supply and regulation allows”.
However, the NHS stresses that people should not delay a vaccine in order to get both vaccinations at the same time.
Family doctors were also instructed to offer the vaccination to nursing home residents before November 1.
“The sites should prepare to start vaccinating as soon as possible,” the letter said.
“We are expected to open the national booking system for bookings on Monday 20 September and issue the first national invitations.”
The letter adds, “Vaccination of health and social workers can begin immediately in hospital centers.
“This should be given with a flu vaccine whenever possible.”
It stated that the national booking system “will be open to people if they are eligible six months after their second vaccination, with priority to” the most vulnerable and those with the longest interval since the second dose of their main course “. .
The vaccine to be used states: “We don’t expect to go live immediately with half the doses of Moderna.
“Sites should not give Moderna boosters at half dose until directed to do so.
“In the meantime, systems should start giving booster vaccinations with Pfizer.”
The news comes from an interim analysis of the safety and effectiveness of Moderna booster doses published in the journal Nature.
A small study looked at a number of people who offered a third dose of the vaccine and an adapted booster variant as part of a phase 2 study.
About 80 participants took part and showed elevated antibody levels after a booster.
Jonathan Ball, Professor of Molecular Virology at the University of Nottingham, commented on the study: “This confirms that an additional boost to an mRNA vaccine, in this case a high or lower dose of the Moderna vaccine, increases levels of virus-killing antibodies Blood, especially those that can kill variants of concern.
“This is true regardless of whether the vaccine spike protein sequence matches the original virus strain or the beta variant.”
Meanwhile, the company behind the Moderna vaccine said its own analysis showed a lower risk of a breakthrough infection where someone could get the virus despite being vaccinated in those who received their first dose recently.
The US-based company said participants in the open-label portion of their Phase 3 study who had their first vaccination an average of eight months earlier had a lower risk of contracting coronavirus than those who had their first Had vaccination 13 months earlier.
Moderna, who said its study would be submitted for peer-reviewed publication, said its data demonstrate the effects of declining immunity and the potential benefits of a booster dose.
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