The terrifying footage shows hundreds of rodents roaming free while hospital patients are reported to have been bitten.
People who live in New South Wales, Australia say they are enduring their worst mouse plague “in decades”.
A shock grain harvest follows, during which the tiny animals have grown in large numbers.
The footage shows hundreds of tiny rodents swarming around a farm in the town of Gilgandra.
“At night … the ground just moves with thousands and thousands of mice just walking around,” Farmer Ron Mckay told the Australian Broadcasting Corporation.
Supermarkets store food in sealed containers and at least three patients at the local hospital have been bitten by the mice, the broadcaster said.
“You can imagine that every time you open a closet, when you go into your pantry, there are mice present,” said Steve Henry, a rodent expert.
“And they eat in your food containers, they stain your clean laundry in your linen closet, they run across your bed at night.”
Farmers who have made bales of hay for the winter expect to lose many to the fast-breeding rodents.
Local media reported that just one pair of mice can produce up to 500 offspring on average in one season.
Intensive bait programs have so far had little success against the infestation, and locals are hoping for heavy rain to drown the mice in their burrows.